This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for eva...
This enzymology textbook for graduate and advanced undergraduate students covers the syllabi of most universities where this subject is regularly taught. It focuses on the synchrony between the two broad mechanistic facets of enzymology: the chemical and the kinetic, and also highlights the synergy between enzyme structure and mechanism. Designed f...
This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as "evo-devo,&quo...
This book contains the proceedings of the International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants, where many plant and animal reproductive biologists gathered to discuss their recent progress in investigating the shared mechanisms and factors involved in sexual reproduction. This now is the first book that reviews re...
This free book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a r...
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications.
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study ...
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clini...
The oceans and atmosphere interact through various processes, including the transfer of momentum, heat, gases and particles. In this book leading international experts come together to provide a state-of-the-art account of these exchanges and their role in the Earth-system, with particular focus on gases and particles. Chapters in the book cover: ...
Universities and research institutes are increasingly expected to contribute to society by creating innovation from the returns of their research results and the establishment of new technologies. Toward that goal, Keio University in Japan held an international symposium titled "Fulfilling the Promise of Technology Transfer: Fostering Innovati...
A PDF version of this book is available for free in open access via the OAPEN Library platform, www.oapen.org. This book presents a new model of accountability which ensures that public-private partnerships don't erode public accountability. It defines concrete accountability standards for different types of partnerships....
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspe...
This book maps the youth transitions of descendants of migrants from Turkey living in Amsterdam and Strasbourg, through a comparative mixed-methods research design. As such, it is of interest to discussions in youth sociology, social mobility and second-generation research. The book follows transition trajectories of the second-generation, from sch...
'This is an incredibly audacious book. Derek Bolton and Grant Gillett brilliantly succeed in providing the big picture that was lacking in the defense of the biopsychosocial model promoted by Engel 40 years ago.' - Steeves Demazeux, Assistant Professor in philosophy, Bordeaux-Montaigne University, FranceThis book is a systematic update of...
'This is an excellent and engaging resource on delusions. The idea that delusions should not be seen as radically different from other beliefs… is an important challenge to much contemporary thinking and practice. It should be of interest to anyone studying delusional beliefs, and to all those who aim to help people who are troubled by them....
This book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecula...
Resilience has become an important topic on the safety research agenda and in organizational practice. Most empirical work on resilience has been descriptive, identifying characteristics of work and organizing activity which allow organizations to cope with unexpected situations. Fewer studies have developed testable models and theories that can be...
This book analyses the interplay between governing, evaluation and knowledge with an empirical focus on Swedish higher education. It investigates the origins, logics, and mechanisms of evaluation and quality assurance reforms and their dynamic interactions with institutional, national and European policy contexts. The chapters report findings from ...
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are i...
The objective of this book is to broadly illustrate the key aspects of water governance, mapping the spectrum of decision-making from techno-centric and eco-centric approaches, to hybrid concepts and people-centric approaches. Topics covered include the challenges for water-governance models, the polycentric model, the integration challenge, water ...
The InfoSec Handbook offers the reader an organized layout of information that is easily read and understood. Allowing beginners to enter the field and understand the key concepts and ideas, while still keeping the experienced readers updated on topics and concepts.
It is intended mainly for beginners to the field of information security, writte...
This book presents simple, robust pre-field screening protocols that allow plant breeders to screen for enhanced tolerance to heat stress in rice. Two critical heat-sensitive stages in the lifecycle of the rice crop are targeted – the seedling and flowering stages – with screening based on simple phenotypic responses. The protocols are based on...
This book covers the latest in snow sport epidemiology, snow sport injuries and treatment, and biomechanical/mechanical engineering related to snow sports injuries (mechanisms of injury, injury prevention by equipment design, injury prevention by design of resort features, and more). It brings together a collection of papers from the International ...
This book deals with contestations "from below" of legal policies and implementation practices in asylum and deportation. Consequently, it covers three types of mobilization: solidarity protests against the deportation of refused asylum seekers, refugee activism campaigning for residence rights and inclusion, and restrictive protests agai...
This book applies for the first time emerging concepts of socioeconomics to analyse an economic sector, namely agriculture. It considers the rational choices of all actors in the system (just as agricultural economists do) and their cultural preferences and constraints (just as rural sociologists do). Socioeconomic concepts are subsequently used to...
This edited volume is concerned with the evolution and achievements of cooperation in research and innovation between Africa and Europe, and points to the need for more diversified funding and finance mechanisms, and for novel models of collaboration to attract new actors and innovative ideas. It reflects on the political, economic, diplomatic and ...
This book offers an analytical presentation of how Europe has created its own version of collective actions. In the last three decades, Europe has seen a remarkable proliferation of collective action legislation, making class actions the most successful export product of the American legal scholarship. While its spread has been surrounded by distru...
This book looks at how a democracy can devolve into a post-factual state.The media is being flooded by populist narratives, fake news, conspiracy theories and make-believe. Misinformation is turning into a challenge for all of us, whether politicians, journalists, or citizens. In the age of information, attention is a prime asset and may be convert...
This open access volume provides evidence-based knowledge on European solidarity and citizen responses in times of crisis. Does the crisis of European integration translate into a crisis of European solidarity, and if yes, what are the manifestations at the level of individual citizens? How strongly is solidarity rooted at the individual level, bot...
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example...
This book presents the results from the Japanese Fisheries Research Agency's 3-year intensive monitoring of radionuclides in a variety of fish, plankton, benthos, and their living environments after the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in March 2011. The book reveals the dynamics of contamination processes in marine and fr...
This book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in...
This book discusses the important issue of the socioeconomic and environmental impacts of agricultural residue burning, common in agricultural practices in many parts of the world. In particular, it focuses on the pollution caused by rice residue burning using primary survey data from Punjab, India. It discusses emerging solutions to agricultural w...